Anti-MAPK14 (T180/Y182) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q16539
Gene Id	1432
Gene Symbols	MAPK14
Protein Name / Synonyms	MAPK14 (T180/Y182)
Clonality	Polyclonal
Preparation	This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-192 amino acids from human MAPK14.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Angiogenesis, Cancer, Inflammation, MAPK Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

Specificity

Predicted Reactivity

Rat, Zebrafish

Other Names

MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; Stress-activated protein kinase 2a

NCBI Accession #

NP_001306.1;NP_620581.1;NP_620582.1;NP_620583.1

Other Accession #

P70618; P47811; Q9DGE2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

41293

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of anti-MAPK14 Antibody (T180/Y182) (Cat# 102-17197) in mouse lung tissue lysates (35ug/lane). MAPK14 (arrow) was detected using the purified Pab.
	MAPK14 Antibody (T180/Y182)(Cat# 102-17197) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MAPK14 Antibody (T180/Y182) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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