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Anti-MAVS (C-term) Antibody
Catalog #: 102-12161
Rabbit Anti-Human MAVS (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q7Z434 |
| Gene Id | 57506 |
| Gene Symbols | MAVS |
| Protein Name / Synonyms | MAVS (C-term) |
| Clonality | Polyclonal |
| Preparation | This MAVS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of human MAVS. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).
Specificity
Other Names
MAVS; IPS1; KIAA1271; VISA; Mitochondrial antiviral-signaling protein; CARD adapter inducing interferon beta; Interferon beta promoter stimulator protein 1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter
NCBI Accession #
NP_001193420.1;NP_065797.2
Other Accession #
NP_065797.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
56528
Recommended Dilutions
WB: 1:1000
 | MAVS Antibody (C-term) (Cat# 102-12161) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MAVS antibody detected the MAVS protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.