Anti-MBP (Y203) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P02686
Gene Id	4155
Gene Symbols	MBP
Protein Name / Synonyms	MBP (Y203)
Clonality	Polyclonal
Preparation	This MBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-209 amino acids from human MBP.
Concentration (lot specific)	0.370 mg/ml
Recommended Applications	Western Blotting
Research Area	Neuroscience
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

MBP is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Specificity

Other Names

MBP; Myelin basic protein; Myelin A1 protein; Myelin membrane encephalitogenic protein

NCBI Accession #

NP_001020252.1;NP_001020261.1;NP_001020263.1;NP_001020271.1;NP_001020272.1;NP_002376.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

33117

Recommended Dilutions

WB: 1:1000

Western blot analysis of anti-MBP Antibody (Y203) (Cat# 102-15128) in NCI-H460 cell line lysates (35ug/lane). MBP(arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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