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Anti-MCAM (C-term) Antibody
Catalog #: 102-15129
Rabbit Anti-Human MCAM (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P43121 |
| Gene Id | 4162 |
| Gene Symbols | MCAM |
| Protein Name / Synonyms | MCAM (C-term) |
| Clonality | Polyclonal |
| Preparation | This MCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-558 amino acids from the C-terminal region of human MCAM. |
| Concentration (lot specific) | 0.300 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Angiogenesis |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Specificity
Other Names
MCAM; MUC18; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen=CD146; Flags: Precursor
NCBI Accession #
NP_006491.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
71607
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of MCAM Antibody (C-term) (Cat# 102-15129) in A2058 cell line lysates (35ug/lane). MCAM (arrow) was detected using the purified Pab. |
 | MCAM Antibody (C-term) (Cat# 102-15129)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MCAM Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.