Anti-MCSF Receptor (CSF1R) (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P07333
Gene Id	1436
Gene Symbols	CSF1R
Protein Name / Synonyms	MCSF Receptor (CSF1R) (C-term)
Clonality	Polyclonal
Preparation	This MCSF Receptor (CSF1R) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-971 amino acids from the C-terminal region of human MCSF Receptor (CSF1R).
Concentration (lot specific)	0.45 mg/ml
Recommended Applications	FC, Western Blotting, IHC-P
Research Area	Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

CSF1R is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. This protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.

Specificity

Other Names

CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; Proto-oncogene c-Fms; CD_antigen=CD115; Flags: Precursor

NCBI Accession #

NP_005202.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

107984

Recommended Dilutions

WB: 1:1000; FC: 1:10-50; IHC: 1:10-50

	Western blot analysis of anti-CSF1R Pab (Cat# 102-17447) in human placenta. CSF1R (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
	Western blot analysis of CSF1R (arrow) using rabbit polyclonal CSF1R Antibody (C-term)(Cat# 102-17447). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CSF1R gene (Lane 2) (Origene Technologies).
	MCSF Receptor (CSF1R) Antibody (C-term) (Cat# 102-17447) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CSF1R Antibody (C-term) (Cat# 102-17447), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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