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Anti-MEKK4 (MAP2K4) (S257) Antibody
Catalog #: 102-17697
Rabbit Anti-Human MEKK4 (MAP2K4) (S257) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P45985 |
| Gene Id | 6416 |
| Gene Symbols | MAP2K4 |
| Protein Name / Synonyms | MEKK4 (MAP2K4) (S257) |
| Clonality | Polyclonal |
| Preparation | This MEKK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEKK4(MAP2K4). |
| Concentration (lot specific) | 0.350 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
Specificity
Predicted Reactivity
Mouse, Xenopus
Other Names
MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; JNK-activating kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; Stress-activated protein kinase kinase 1; c-Jun N-terminal kinase kinase 1
NCBI Accession #
NP_001268364.1;NP_003001.1
Other Accession #
P47809; Q07192
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
44288
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of MAP2K4 (arrow) using rabbit polyclonal MAP2K4 Antibody (S257) (Cat# 102-17697).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP2K4 gene (Lane 2) (Origene Technologies). |
 | Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with MAP2K4 Antibody (S257) (Cat# 102-17697), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.