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Anti-Mesothelin (C-term) Antibody
Catalog #: RB-16-0002
Rabbit anti-Mesothelin(C-terminus) Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | Q13421 |
| Gene Id | 10232 |
| Gene Symbols | MSLN MPF |
| Clonality | Polyclonal |
| Immunogen | The imunogen was synthetic peptide. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Recommended Applications | ELISA (recommended work dilution= 1: 2, 000) |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Research Area | Cancer |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Mesothelin (MSLN) may play an important role in cellular adhesion. It presents on normal mesothelial cells lining the pleura, peritoneum and pericardium. Since mesothelin is overexpressed in some cancers such as mesothelioma and ovarian and pancreatic adenocarcinoma, it could be a potential tumor biomarker. Mesothelin is immunogenic, and it also may be the potential antigenic target of a therapeutic cancer vaccine.
Specificity
This antibody binds to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. Cross reactivity with mouse and rat Mesothelin has not yet been tested.
Storage
Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4°C. Please avoid multiple freeze-thaw cycles, as this will lower the activity of the antibody.
Related Products
- Mouse Anti-Human Mesothelin (catalog #: DS-MB-01886)
- Recombinant Human Mesothelin / Megakaryocyte-Potentiating Factor (MPF) (catalog #: 230-00043-100)
References
- Onda M, et al..(2006) Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma. Clin Cancer Res. 12(14 Pt 1):4225-31.
- Ho M, et al.. (2005) Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. Clin Cancer Res. 11(10):3814-20.
Expiration:
12 months from the date of shipment when stored properly.