Anti-MKNK1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9BUB5
Gene Id	8569
Gene Symbols	MKNK1
Protein Name / Synonyms	MKNK1 (N-term)
Clonality	Polyclonal
Preparation	This MKNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MKNK1.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence.C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also binds strongly to the stress-activated kinase, p38.

Specificity

Predicted Reactivity

Mouse

Other Names

MKNK1; MNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1

NCBI Accession #

NP_001129025.1;NP_003675.2;NP_945324.1

Other Accession #

O08605

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

51342

Recommended Dilutions

WB: 1:1000

The anti-MKNK1 Pab (Cat# 102-17154) is used in Western blot to detect MKNK1 in A2058 tissue lysate

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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