Anti-MLF1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P58340
Gene Id	4291
Gene Symbols	MLF1
Protein Name / Synonyms	MLF1 (N-term)
Clonality	Polyclonal
Preparation	This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human MLF1.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Specificity

Other Names

MLF1; Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1

NCBI Accession #

NP_001123628.1;NP_001123629.1;NP_001182361.1;NP_001182362.1;NP_001182363.1;NP_071888.1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

30627

Recommended Dilutions

WB: 1:1000

	Western blot analysis of MLF1 Antibody (N-term) (Cat# 102-16905) in mouse heart tissue lysates (35ug/lane). MLF1 (arrow) was detected using the purified Pab.
	Western blot analysis of MLF1 (arrow) using rabbit polyclonal MLF1 Antibody (N-term) (Cat# 102-16905). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MLF1 gene.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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