Anti-MMP2 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P08253
Gene Id	4313
Gene Symbols	MMP2
Protein Name / Synonyms	MMP2 (Center)
Clonality	Polyclonal
Preparation	This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Angiogenesis, Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Specificity

Predicted Reactivity

Mouse, Rat, Chicken, Rabbit

Other Names

MMP2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; TBE-1; PEX

NCBI Accession #

NP_001121363.1;NP_004521.1

Other Accession #

P33436; P50757; P33434; Q90611; NP_004521.1; NP_001121363.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

73882

Recommended Dilutions

WB: 1:1000

	MMP2 Antibody (Center) (Cat# 102-12101) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the MMP2 antibody detected the MMP2 protein (arrow).
	Western blot analysis of MMP2 (arrow) using rabbit polyclonal MMP2 Antibody (Center) (Cat# 102-12101). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MMP2 gene.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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