Anti-MMP7 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P09237
Gene Id	4316
Gene Symbols	MMP7
Protein Name / Synonyms	MMP7 (Center)
Clonality	Polyclonal
Preparation	This MMP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the Central region of human MMP7.
Concentration (lot specific)	2.000 mg/ml
Recommended Applications	Western Blotting, IHC-P, IF
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP7 degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Specificity

Other Names

MMP7; MPSL1; PUMP1; Matrilysin; Matrin; Matrix metalloproteinase-7; Pump-1 protease; Uterine metalloproteinase

NCBI Accession #

NP_002414.1

Other Accession #

NP_002414

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

29677

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100; IF: 1:10-50

	The anti-MMP7 (Center) Pab (Cat# 102-16680) is used in Western blot to detect MMP7 in 293 cell lysate.
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
	Confocal immunofluorescent analysis of MMP7 Antibody (Center) (Cat# 102-16680) with 293 cell followed by Alexa Fluor^® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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