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Anti-Mouse CD86 Antibody, Biotinylated
Catalog #: 135-01041
Mouse CD86 Biotinylated Antibody [clone: GL1], monoclonal Rat IgG2a, kappa. Validated for flow cytometry.
Product Description
Specifications
| Size | 100 µg, 500 µg |
| Estimated Lead Time | 3-5 business days |
| Species | Mouse |
| Host Species | Rat |
| Clonality | Monoclonal |
| Clone | GL1 |
| Conjugation | Biotin |
| Preparation | The antibody was purified by affinity chromatography, and conjugated with biotin. |
| Isotype | IgG2a Kappa |
| Format | Liquid |
| Concentration (lot specific) | 0.5 mg/mL |
| Buffers | PBS, pH 7.2-7.4, 0.2% BSA, 0.1% sodium azide |
| Recommended Applications | Flow Cytometry |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | 4°C |
Description
Product Features
- Serum-free media used for cell culture of hybridomas to minimize bovine antibody contamination
- Gentle elution at pH 4.0 to minimize antibody degradation
- Protein A, G & L affinity purification
- High purity
Description
CD86 is an 80 kD Ig superfamily member also known as B7.2. CD86 is expressed on mature dendritic cells, macrophages, astrocytes and activated B cells and T cells. As costimulatory factors, CD86 and CD80, interact with CD28 and CD152 (CTLA-4) to regulate T cell activation, with CD28 transducing activation signal, and CTLA4 transducing inhibitory signal. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity.