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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Host Species | Rabbit |
| Accession Number | Q9WV60 |
| Gene Id | 56637 |
| Gene Symbols | GSK3B |
| Protein Name / Synonyms | Gsk3b (N-term) |
| Clonality | Polyclonal |
| Preparation | This Mouse Gsk3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of mouse Gsk3b. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Cardiovascular Disease, Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).
Specificity
Predicted Reactivity
Human, Rat
Other Names
Gsk3b; Glycogen synthase kinase-3 beta; Serine/threonine-protein kinase GSK3B
NCBI Accession #
NP_062801.1
Other Accession #
P18266; P49841; NP_062801.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
46710
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Mouse Gsk3b Antibody (N-term) (Cat# 102-12683) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Gsk3b antibody detected the Gsk3b protein (arrow). |
 | Mouse Gsk3b Antibody (N-term) (102-12683)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Gsk3b Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
MOUSE
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.