Anti-Mouse Irf3 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rabbit
Accession Number	P70671
Gene Id	54131
Gene Symbols	IRF3
Protein Name / Synonyms	Irf3 (N-term)
Clonality	Polyclonal
Preparation	This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Concentration (lot specific)	0.350 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).

Specificity

Predicted Reactivity

Bovine, Pig

Other Names

Irf3; Interferon regulatory factor 3

NCBI Accession #

NP_058545.1

Other Accession #

Q764M6; Q4JF28; NP_058545.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

46852

Recommended Dilutions

WB: 1:1000

MOUSE Irf3 Antibody (N-term) (Cat# 102-14538) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MOUSE Irf3 antibody detected the MOUSE Irf3 protein (arrow).

Antigen Source

MOUSE

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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