This antibody recognizesmurine Ly-6C, a 14kD differentiation antigen, which is expressed on macrophage/dendritic cell precursors in mid-stage development (late CFU-M, monoblasts and immature monocytes), granulocytes, and on a wide range of endothelial cells and subpopulations of B- and T-lymphocytes.

Using this product, distinct mouse blood monocyte subsets can be distinguished: immature Ly-6C^hi monocytes are recruited to acute peripheral inflammation and develop into Ly-6C⁺ exudate macrophages, whereas more mature Ly-6C^-/lo monocytes are precursors for tissue macrophages and dendritic cells in steady state.

IgG concentration 1.0 mg/ml