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Anti-Mouse Mammaglobin Antibody, Biotinylated

Catalog #: RB-14-0005B-50

Rabbit anti-Mouse Mammaglobin Biotinylated Antibody, 50 ug

Product Description

Specifications

Size50 µg
Estimated Lead Time1-2 business days
SpeciesMouse
Host SpeciesRabbit
Accession Number
AY217100
ClonalityPolyclonal
Immunogen
This antibody was produced from a rabbit immunized with the KLH-conjugated peptide derived from human Mammglobin as immunogen. The IgG fraction (lyophilized antibody) of immunized serum was purified by affinity chromatography.
IsotypeIgG
Recommended ApplicationsELISA (recommended work dilution= 1:10e4), Western Blotting (recommended work dilution= 1:500-1000)
Reconstitution
A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial.
Research AreaCardiovascular Disease
Shipping TypeAmbient temperature
Storage-20°C

Description

Description

Mammaglobin (MAM) is a member of the secretoglobin superfamily, which also includes uteroglobin (Clara cell protein; Clara cell 10 kDa protein), lymphoglobin, and the lipophilins A, B (BU101), and C (lacryglobin; mammaglobin B). In human breast tissue, mammaglobin is secreted as a glycosylated peptide, which is covalently associated with lipophilin B. Mammaglobin, a mammary-specific member of the uteroglobin family, is known to be overexpressed in human breast cancer. It has been used as a specific molecular marker for breast cancer diagnosis. Mammaglobin is expressed mainly by breast epithelial cells, and this feature has been used to detect circulating breast cancer cells and occult metastases in sentinel axillary lymph nodes of breast cancer patients.

Storage / Stability

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

Specificity

The antibody detects specifically target derived from human protein by ELISA and Dot Blotting. Cross reactivity with mouse and rat are not tested yet.

References

  • Alvarez, J, Vinas, J, Alonso, JM, Albar, JP, Ashman, K, Dominguez, P: Characterization and cloning of two isoforms of heteroglobin, a novel heterodimeric glycoprotein of the secretoglobin-uteroglobin family showing tissue-specific and sex differential expression. J Biol Chem 2002 233–242,
  • Carter, D, Douglass, JF, Cornellison, CD, et al: Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer. Biochemistry 2002 41: 6714–6722,
Expiration:
12 months from the date of shipment when stored properly.