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Anti-Mouse Mammaglobin Antibody
Catalog #: RB-14-0005
Rabbit Anti-Mouse Mammaglobin Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Mouse |
| Accession Number | AY217100 |
| Clonality | Polyclonal |
| Immunogen | This antibody was produced from a rabbit immunized with the KLH-conjugated peptide derived from human Mammglobin as immunogen. The IgG fraction (lyophilized antibody) of immunized serum was purified by affinity chromatography. |
| Recommended Applications | ELISA (recommended work dilution= 1:10e4), Western Blotting (recommended work dilution= 1:500-1000) |
| Reconstitution | Supplied as lyophilized purified antibody. The antibody is stable for at least a few years from the data of receipt when stored at -20°C to -70°C. Reconstituted antibody (recommended with H20 1 mg/ml) can also be aliquoted and stored frozen at -20°C to -70°C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can be stored at 4°C for 1 month. If 1 ml of H20 is used, the antibody concentration will be 100 µg/ml. Please avoid freeze-thaw cycles. |
| Research Area | Cardiovascular Disease |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Mammaglobin (MAM) is a member of the secretoglobin superfamily, which also includes uteroglobin (Clara cell protein; Clara cell 10 kDa protein), lymphoglobin, and the lipophilins A, B (BU101), and C (lacryglobin; mammaglobin B). In human breast tissue, mammaglobin is secreted as a glycosylated peptide, which is covalently associated with lipophilin B. Mammaglobin, a mammary-specific member of the uteroglobin family, is known to be overexpressed in human breast cancer. It has been used as a specific molecular marker for breast cancer diagnosis. Mammaglobin is expressed mainly by breast epithelial cells, and this feature has been used to detect circulating breast cancer cells and occult metastases in sentinel axillary lymph nodes of breast cancer patients.
Specificity
The antibody detects specifically target derived from human protein by ELISA and Dot Blotting. Cross reactivity with mouse and rat are not tested yet.
Storage
Store at -20°C, if not intended for use within a month, Keep it at 4°C and minimize freezing and thawing when use.
References
- Alvarez, J, Vinas, J, Alonso, JM, Albar, JP, Ashman, K, Dominguez, P: Characterization and cloning of two isoforms of heteroglobin, a novel heterodimeric glycoprotein of the secretoglobin-uteroglobin family showing tissue-specific and sex differential expression. J Biol Chem 2002 233242,
- Carter, D, Douglass, JF, Cornellison, CD, et al: Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer. Biochemistry 2002 41: 67146722,
Expiration:
12 months from the date of shipment when stored properly.