Anti-Mouse p21Cip1 (C-term S148) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rabbit
Accession Number	P39689
Gene Id	12575
Gene Symbols	CDKN1A
Protein Name / Synonyms	p21Cip1 (C-term S148)
Clonality	Polyclonal
Preparation	This Mouse p21Cip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-154 amino acids from the C-terminal region of mouse p21Cip1.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Specificity

Other Names

Cdkn1a;Cip1; Waf1; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Cyclin-dependent kinase inhibitor 1; Melanoma differentiation-associated protein; Cyclin-dependent kinase inhibitor 1; p21

NCBI Accession #

NP_001104569.1;NP_031695.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

17785

Recommended Dilutions

WB: 1:1000

Mouse p21Cip1 Antibody (C-term S148) (Cat# 102-14759) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Mouse p21Cip1 antibody detected the Mouse p21Cip1 protein (arrow).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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