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Anti-Mouse Phospho-mouse CASP3 (S12) Antibody
Catalog #: 102-15586
Rabbit Anti-Mouse Phospho-mouse CASP3(S12) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Host Species | Rabbit |
| Accession Number | P70677 |
| Gene Id | 12367 |
| Gene Symbols | CASP3 |
| Protein Name / Synonyms | Phospho-CASP3(S12) |
| Clonality | Polyclonal |
| Preparation | This mouse CASP3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of mouse CASP3. |
| Concentration (lot specific) | 0.300 mg/ml |
| Recommended Applications | Dot Blotting |
| Research Area | Apoptosis, Cardiovascular Disease, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].
Specificity
Other Names
Casp3; Cpp32; Caspase-3; Apopain; Cysteine protease CPP32; LICE; Protein Yama; SREBP cleavage activity 1; Caspase-3 subunit p17; Caspase-3 subunit p12
NCBI Accession #
NP_033940.1
Other Accession #
NP_033940.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
31475
Recommended Dilutions
DB: 1:500
 | Dot blot analysis of Phospho-mouse CASP3-S12 Antibody Phospho-specific Pab (Cat# 102-15586) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
Antigen Source
MOUSE
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.