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Anti-Mouse Prr5 (C-term) Antibody
Catalog #: 102-14246
Rabbit Anti-Mouse Prr5 (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Host Species | Rabbit |
| Accession Number | Q812A5 |
| Gene Id | 109270 |
| Gene Symbols | PRR5 |
| Protein Name / Synonyms | Prr5 (C-term) |
| Clonality | Polyclonal |
| Preparation | This Mouse Prr5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of mouse Prr5. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).
Specificity
Other Names
Prr5; Protor1; Proline-rich protein 5; Protein observed with Rictor-1
NCBI Accession #
NP_666173.4
Other Accession #
NP_666173.4
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
42523
Recommended Dilutions
WB: 1:1000
 | Mouse Prr5 Antibody (C-term)(Cat# 102-14246) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Prr5 antibody detected the Prr5 protein (arrow). |
Antigen Source
MOUSE
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.