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Anti-Mouse Shc1 (Center) Antibody
Catalog #: 102-14362
Rabbit Anti-Mouse Shc1(Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Host Species | Rabbit |
| Accession Number | P98083 |
| Gene Id | 20416 |
| Gene Symbols | SHC1 |
| Protein Name / Synonyms | Shc1(Center) |
| Clonality | Polyclonal |
| Preparation | This Mouse Shc1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-405 amino acids from the Central region of mouse Shc1. |
| Concentration (lot specific) | 0.290 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Angiogenesis, Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
Specificity
Other Names
Shc1; Shc; ShcA; SHC-transforming protein 1; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1
NCBI Accession #
NP_001106802.1;NP_035498.2
Other Accession #
NP_001106802.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
62608
Recommended Dilutions
WB: 1:1000
 | Mouse Shc1 Antibody (Center) (Cat# 102-14362) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Mouse Shc1 antibody detected the Mouse Shc1 protein (arrow). |
Antigen Source
MOUSE
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.