Anti-Mouse TREM-1 Antibody

Product Description

Specifications

Size	0.1 mg
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rat
Protein Name / Synonyms	TREM-1
Concentration (lot specific)	1.0mg/ml
Recommended Applications	Immunohistology - Frozen, Flow Cytometry, Immunofluorescence, Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Specificity

This product recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1.

TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:

Purified IgG - liquid

Formulation:

Phosphate buffered saline

Format Type:

Purified

Preparation

Immunogen:

Mouse TREM-1 Fc fusion protein

Preservative:

0.09%

Sodium Azide (NaN₃)

Expiration:

12 months from the date of shipment when stored properly.

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