Anti-MST1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q13043
Gene Id	6789
Gene Symbols	STK4
Protein Name / Synonyms	MST1 (C-term)
Clonality	Polyclonal
Preparation	This MST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-415 amino acids from the C-terminal region of human MST1.
Concentration (lot specific)	1.130 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

MST1 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it is possible that this protein induces the chromatin condensation observed in this process.

Specificity

Predicted Reactivity

Bovine

Other Names

STK4; KRS2; MST1; Serine/threonine-protein kinase 4; Mammalian STE20-like protein kinase 1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase 4 18kDa subunit

NCBI Accession #

NP_006273.1

Other Accession #

Q5E9L6

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

55630

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of anti-MST1 Pab (Cat# 102-17700) in HL60 cell lysate. MST1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
	Western blot analysis of STK4 (arrow) using MST1 Antibody (C-term) (Cat# 102-17700).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the STK4 gene (Lane 2) (Origene Technologies).
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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