Anti-MYC (T58) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P01106
Gene Id	4609
Gene Symbols	MYC
Protein Name / Synonyms	MYC (T58)
Clonality	Polyclonal
Preparation	This MYC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from human MYC.
Concentration (lot specific)	0.350 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Specificity

Predicted Reactivity

Mouse, Rat, Zebrafish, Bovine, Chicken, Pig, Xenopus

Other Names

MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; Proto-oncogene c-Myc; Transcription factor p64

NCBI Accession #

NP_002458.2

Other Accession #

P09416; Q29031; P01108; P01109; Q2HJ27; P24793; Q63379; P03966; P04198; Q9PSJ0; P18444; P15171; Q7ZVS9; P52160; P06171

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

48804

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of MYC (arrow) using rabbit polyclonal MYC Antibody (T58) (Cat# 102-14454). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MYC gene (Lane 2) (Origene Technologies).
	Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with MYC Antibody (T58) (Cat# 102-14454), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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