Rabbit Anti-Human NAE1 (APPBP1) (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q13564 |
| Gene Id | 8883 |
| Gene Symbols | NAE1 |
| Protein Name / Synonyms | NAE1 (APPBP1) (C-term) |
| Clonality | Polyclonal |
| Preparation | This NAE1 (APPBP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human NAE1 (APPBP1). |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPB1 is required for cell cycle progression through the S/M checkpoint.
Specificity
Predicted Reactivity
Mouse, Rat, Monkey
Other Names
NAE1; APPBP1; NEDD8-activating enzyme E1 regulatory subunit; Amyloid beta precursor protein-binding protein 1, 59 kDa; Amyloid protein-binding protein 1; Proto-oncogene protein 1
NCBI Accession #
NP_001018169.1;NP_001018170.1;NP_003896.1
Other Accession #
Q9Z1A5; Q8VBW6; Q4R3L6; NP_003896
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
60246
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of anti-APPBP1 Antibody (C-term) (Cat# 102-17238) in mouse brain tissue lysates (35ug/lane). APPBP1(arrow) was detected using the purified Pab. |
 | Western blot analysis of APP-BP1(arrow) using rabbit polyclonal APP-BP1 Antibody (C-term) (Cat# 102-17238). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APP-BP1 gene (Lane 2) (Origene Technologies). |
 | Formalin-fixed and paraffin-embedded human breast carcinoma reacted with anti-APPBP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.