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Anti-Neurokinin A Antibody, Biotinylated
Catalog #: 130-00019B-50
Chicken anti-Neurokinin A Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Chicken |
| Accession Number | P20366 |
| Gene Id | 6863 |
| Gene Symbols | TAC1 NKA NKNA TAC2 |
| Immunogen | The immunogen was a synthetic peptide. This antibody was produced from a rabbit immunized with this peptide conjugated with KLH. The IgG fraction was purified from rabbit serum by Protein G affinity chromatography. |
| Immunogen Sequence | CHKRHKTDSFVGLMGK |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1: 64, 000) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | Neuroscience, Cardiovascular Disease, Inflammation |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Neurokinin A, formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene. Neurokinin A has many excitatory effects on mammalian nervous systems and is also influential on the mammalian inflammatory and pain responses. Neurokinin A is present in excitatory neurons and secretory cells of the hypothalamicpituitaryadrenal axis. Additionally, neurokinin A is found in the neurosensory system and modulates a wide range of inflammatory and tissue repairing processes. Inflammation, tissue healing and cell proliferation has been linked to neurokinin A release into surrounding tissues.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
This antibody specifically binds to human Neurokinin A. Cross reactivity with mouse and rat Neurokinin A was not tested.
References
- Chandrashekar, IR. and Cowsik, SM. (2003). "Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles". Biophys. J. 85 (6): 400211.
- Sun, J. et al. (2008) "Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways." Am J Physiol Cell Physiol. 295(3):C679-91
Expiration:
12 months from the date of shipment when stored properly.