Anti-NFKB (p105) (C-term S933) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P19838
Gene Id	4790
Gene Symbols	NFKB1
Protein Name / Synonyms	NFKB(p105) (C-term S933)
Clonality	Polyclonal
Preparation	This NFKB(p105) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-937 amino acids from the C-terminal region of human NFKB(p105).
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer, Inflammation, NFkB Signaling, Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

Specificity

Predicted Reactivity

Mouse, Rat, Chicken

Other Names

NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NF-kappa-B p50 subunit

NCBI Accession #

NP_001158884.1;NP_003989.2

Other Accession #

Q63369; P25799; Q04861; NP_001158884.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

105356

Recommended Dilutions

WB: 1:1000

NFKB(p105) Antibody (C-term S933) (Cat# 102-14146) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the NFKB antibody detected the NFKB protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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