Anti-NFKBIB (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q15653
Gene Id	4793
Gene Symbols	NFKBIB
Protein Name / Synonyms	NFKBIB (C-term)
Clonality	Polyclonal
Preparation	This NFKBIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-355 amino acids from the C-terminal region of human NFKBIB.
Concentration (lot specific)	0.310 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Specificity

Other Names

NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; I-kappa-B-beta; Thyroid receptor-interacting protein 9

NCBI Accession #

NP_001230045.1;NP_002494.2

Other Accession #

NP_001001716.1; NP_002494.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

37771

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	NFKBIB Antibody (C-term) (Cat# 102-12160) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NFKBIB antibody detected the NFKBIB protein (arrow).
	NFKBIB Antibody (C-term) (102-12160)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NFKBIB Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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