Anti-NLRC4 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9NPP4
Gene Id	58484
Gene Symbols	NLRC4
Protein Name / Synonyms	NLRC4 (N-term)
Clonality	Polyclonal
Preparation	This NLRC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the N-terminal region of human NLRC4.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

Specificity

Other Names

NLRC4; CARD12; CLAN; CLAN1; IPAF; NLR family CARD domain-containing protein 4; CARD, LRR, and NACHT-containing protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor

NCBI Accession #

NP_001186067.1;NP_001186068.1;NP_067032.3

Other Accession #

NP_067032.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

116159

Recommended Dilutions

WB: 1:1000

NLRC4 Antibody (N-term) (Cat# 102-11955) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the NLRC4 antibody detected the NLRC4 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products