Rabbit Anti-Human NLRP3 (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q96P20 |
| Gene Id | 114548 |
| Gene Symbols | NLRP3 |
| Protein Name / Synonyms | NLRP3 (N-term) |
| Clonality | Polyclonal |
| Preparation | This NLRP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human NLRP3. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Inflammation, Innate Immunity |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis.
Specificity
Other Names
NLRP3; C1orf7; CIAS1; NALP3; PYPAF1; NACHT, LRR and PYD domains-containing protein 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1
NCBI Accession #
NP_001073289.1;NP_001120933.1;NP_001120934.1;NP_001230062.1;NP_004886.3;NP_899632.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
118173
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of NLRP3 Antibody (N-term) (Cat# 102-17920) in MDA-MB231 cell line lysates (35ug/lane).NLRP3 (arrow) was detected using the purified Pab. |
 | NLRP3 Antibody (N-term) (Cat# 102-17920) immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the NLRP3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.