Anti-NOX4 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9NPH5
Gene Id	50507
Gene Symbols	NOX4
Protein Name / Synonyms	NOX4 (N-term)
Clonality	Polyclonal
Preparation	This NOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-153 amino acids from the N-terminal region of human NOX4.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cardiovascular Disease, Inflammation, Oxidative Stress
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.

Specificity

Other Names

NOX4; RENOX; NADPH oxidase 4; Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase

NCBI Accession #

NP_001137308.1;NP_058627.1

Other Accession #

NP_001137308.1; NP_058627.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

66932

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	NOX4 Antibody (N-term) (Cat# 102-12263) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NOX4 antibody detected the NOX4 protein (arrow).
	NOX4 Antibody (N-term) (102-12263)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NOX4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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