Anti-NPM1 Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P06748
Gene Id	4869
Gene Symbols	NPM1
Protein Name / Synonyms	NPM1
Clonality	Monoclonal
Preparation	Purified His-tagged NPM1 protein was used to produced this monoclonal antibody.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.

Specificity

Other Names

NPM1;NPM; Nucleophosmin; Nucleophosmin; Nucleolar phosphoprotein B23; Nucleophosmin; Nucleolar protein NO38; Nucleophosmin; Numatrin

NCBI Accession #

NP_001032827.1;NP_002511.1;NP_954654.1

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

32575

Recommended Dilutions

WB: 1:1000

NPM1 Antibody (Cat# 102-10420) western blot analysis in Hela,Jurkat,MCF-7,mouse NIH/3T3 cell line lysates (35ug/lane).This demonstrates the NPM1 antibody detected the NPM1 protein (arrow).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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