Rabbit Anti-Human NR1H4 (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q96RI1 |
| Gene Id | 9971 |
| Gene Symbols | NR1H4 |
| Protein Name / Synonyms | NR1H4 (N-term) |
| Clonality | Polyclonal |
| Preparation | This NR1H4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human NR1H4. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
NR1H4 is a Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Specificity
Predicted Reactivity
Bovine
Other Names
NR1H4; BAR; FXR; HRR1; RIP14; Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14
NCBI Accession #
NP_001193906.1;NP_001193907.1;NP_001193908.1;NP_001193921.1;NP_001193922.1;NP_005114.1
Other Accession #
Q3SZL0; NP_005114.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
55914
Recommended Dilutions
WB: 1:1000
 | NR1H4 Antibody (N-term) (Cat# 102-14094) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NR1H4 antibody detected the NR1H4 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.