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Anti-NR1I3 (Center) Antibody
Catalog #: 102-12559
Rabbit Anti-Human NR1I3 (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q14994 |
| Gene Id | 9970 |
| Gene Symbols | NR1I3 |
| Protein Name / Synonyms | NR1I3 (Center) |
| Clonality | Polyclonal |
| Preparation | This NR1I3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human NR1I3. |
| Concentration (lot specific) | 0.400 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificity
Other Names
NR1I3; CAR; Nuclear receptor subfamily 1 group I member 3; Constitutive activator of retinoid response; Constitutive androstane receptor; Orphan nuclear receptor MB67
NCBI Accession #
NP_001070938.1;NP_001070939.1;NP_001070940.1;NP_001070941.1;NP_001070944.1;NP_001070945.1;NP_001070947.1;NP_001070948.1;NP_001070949.1;NP_001070950.1;NP_005113.1
Other Accession #
NP_005113.1; NP_001070948.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
39942
Recommended Dilutions
WB: 1:1000
 | NR1I3 Antibody (Center) (Cat# 102-12559) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NR1I3 antibody detected the NR1I3 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.