Anti-NR3C2 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P08235
Gene Id	4306
Gene Symbols	NR3C2
Protein Name / Synonyms	NR3C2 (Center)
Clonality	Polyclonal
Preparation	This NR3C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the Central region of human NR3C2.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Specificity

Predicted Reactivity

Mouse, Rat, Xenopus

Other Names

NR3C2; MCR; MLR; Mineralocorticoid receptor; Nuclear receptor subfamily 3 group C member 2

NCBI Accession #

NP_000892.2;NP_001159576.1

Other Accession #

Q91573; P22199; Q8VII8; NP_000892.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

107067

Recommended Dilutions

WB: 1:1000

NR3C2 Antibody (Center) (Cat# 102-13318) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the NR3C2 antibody detected the NR3C2 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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