Anti-NUMB (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P49757
Gene Id	8650
Gene Symbols	NUMB
Protein Name / Synonyms	NUMB (N-term)
Clonality	Polyclonal
Preparation	This NUMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NUMB.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

NUMB; Protein numb homolog; Protein S171

NCBI Accession #

NP_001005743.1;NP_001005744.1;NP_001005745.1;NP_003735.3

Other Accession #

Q2LC84; Q9QZS3; NP_003735.3; NP_001005743.1; NP_001005745.1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

70804

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	NUMB Antibody (N-term) (Cat# 102-11099) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NUMB antibody detected the NUMB protein (arrow).
	NUMB Antibody (N-term) (Cat# 102-11099)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMB Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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