Anti-OAS1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P00973
Gene Id	4938
Gene Symbols	OAS1
Protein Name / Synonyms	OAS1 (C-term)
Clonality	Polyclonal
Preparation	This OAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human OAS1.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

Specificity

Other Names

OAS1; OIAS; 2'-5'-oligoadenylate synthase 1; E18/E16; p46/p42 OAS

NCBI Accession #

NP_001027581.1;NP_002525.2;NP_058132.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

46029

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	The anti-OAS1 Pab (Cat# 102-16689) is used in Western blot to detect OAS1 in mouse liver lysate.
	Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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