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Anti-P-Glycoprotein (ABCB1) (Center) Antibody
Catalog #: 102-16643
Rabbit Anti-Human P-Glycoprotein (ABCB1) (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P08183 |
| Gene Id | 5243 |
| Gene Symbols | ABCB1 |
| Protein Name / Synonyms | P-Glycoprotein (ABCB1) (Center) |
| Clonality | Polyclonal |
| Preparation | This P-Glycoprotein (ABCB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-677 amino acids from the Central region of human P-Glycoprotein (ABCB1). |
| Concentration (lot specific) | 2.000 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Specificity
Other Names
ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen=CD243
NCBI Accession #
NP_000918.2
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
141479
Recommended Dilutions
WB: 1:1000
 | ABCB1 Antibody (L661) (Cat# 102-16643) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCB1 antibody detected the ABCB1 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.