Anti-p27Kip1 (N-term S12) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P46527
Gene Id	1027
Gene Symbols	CDKN1B
Protein Name / Synonyms	p27Kip1 (N-term S12)
Clonality	Polyclonal
Preparation	This p27Kip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human p27Kip1.
Concentration (lot specific)	0.260 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease, Cancer, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Specificity

Predicted Reactivity

Hamster

Other Names

CDKN1B; KIP1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1

NCBI Accession #

NP_004055.1

Other Accession #

P46414; Q60439; NP_004055.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

22073

Recommended Dilutions

WB: 1:1000

p27Kip1 Antibody (N-term S12) (Cat# 102-14510) western blot analysis in A431,Hela,mouse C2C12 cell line lysates (35ug/lane).This demonstrates the p27Kip1 antibody detected the p27Kip1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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