Anti-PABPC1 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P11940
Gene Id	26986
Gene Symbols	PABPC1
Protein Name / Synonyms	PABPC1 (Center)
Clonality	Polyclonal
Preparation	This PABPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the Central region of human PABPC1.
Concentration (lot specific)	2.000 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

PABPC1 binds the poly(A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Specificity

Predicted Reactivity

Rat, Bovine, Xenopus

Other Names

PABPC1; PAB1; PABP1; PABPC2; Polyadenylate-binding protein 1

NCBI Accession #

NP_002559.2

Other Accession #

Q6IP09; P20965; Q9EPH8; P29341; P61286

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

70671

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of PABPC1 Antibody (Center) (Cat# 102-15228) in NIH-3T3 cell line lysates (35ug/lane). PABPC1 (arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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