Anti-Pael-R (GPR37) (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O15354
Gene Id	2861
Gene Symbols	GPR37
Protein Name / Synonyms	Pael-R (GPR37) (N-term)
Clonality	Polyclonal
Preparation	This Pael-R (GPR37) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the N-terminal region of human Pael-R (GPR37).
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.

Specificity

Other Names

GPR37; Probable G-protein coupled receptor 37; Endothelin B receptor-like protein 1; Parkin-associated endothelin receptor-like receptor

NCBI Accession #

NP_005293.1

Other Accession #

NP_005293

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

67114

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of anti-Pael-R (GPR37) Pab (Cat# 102-16778) in mouse brain tissue lysate. Pael-R (GPR37) (arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
	Pael Antibody (N-term) (Cat# 102-16778) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the Pael antibody detected the Pael protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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