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Anti-PAI-1 Antibody, Biotinylated
Catalog #: 130-10010B-50
Rabbit anti-PAI-1 Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Specificity | Rabbit Anti-Human PAI-1 antibody detects a target derived from a human recombinant PAI-1 protein aswell as selected cell lysates Cross reactivity with mouse and rat PAI-1 was not determined |
| Host Species | Rabbit |
| Accession Number | NP_000593 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was a synthetic protein derived from Human PAI-1. This antibody was produced from arabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed byProtein A/G affinity chromatography. |
| Immunogen Sequence | CAAMGFKIDDKGMAPALRHLYKE |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1: 20, 000) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | Cardiovascular Disease |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Plasminogen Activator Inhibitor 1 (PAI-1)Also known as SERPINE1, a 45kDa serine protease inhibitorand member of the serpin family, which acts as the primary inhibitor of tissue plasminogen activator(tPA) and urokinase plasminogen activator (uPA), and hence fibrinolysis. Increased levels of PAI-1 areassociated with diabetes, cardiovascular disease and an increased occurrence of thrombosis in obesity,and can be induced by obesity related factors including insulin, glucose and VLDL (very-low-densitylipoprotein).
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
Rabbit Anti-Human PAI-1 antibody detects a target derived from a human recombinant PAI-1 protein aswell as selected cell lysates. Cross reactivity with mouse and rat PAI-1 was not determined.
References
- Sreerama Shetty, et al., (2008) Regulation of plasminogen activator inhibitor-1 expression by tumorsuppressor protein p53. J Biol Chem. 11;283(28): 1957019580
Expiration:
12 months from the date of shipment when stored properly.