Anti-PAICS (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P22234
Gene Id	10606
Gene Symbols	PAICS
Protein Name / Synonyms	PAICS (N-term)
Clonality	Polyclonal
Preparation	This PAICS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human PAICS.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P, FC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Specificity

Predicted Reactivity

Chicken

Other Names

PAICS; ADE2; AIRC; PAIS; Multifunctional protein ADE2; Phosphoribosylaminoimidazole-succinocarboxamide synthase; SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; AIR carboxylase

NCBI Accession #

NP_001072992.1;NP_001072993.1;NP_006443.1

Other Accession #

P38024; NP_001072992.1; NP_006443.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

47079

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; FC: 1:10-50

	PAICS Antibody (N-term) (Cat# 102-11802) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PAICS antibody detected the PAICS protein (arrow).
	PAICS Antibody (N-term) (Cat# 102-11802) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the PAICS antibody detected the PAICS protein (arrow).
	PAICS Antibody (N-term) (Cat# 102-11802)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PAICS Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	PAICS Antibody (N-term) (Cat# 102-11802) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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