Anti-PAK2 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q13177
Gene Id	5062
Gene Symbols	PAK2
Protein Name / Synonyms	PAK2 (N-term)
Clonality	Polyclonal
Preparation	This PAK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-222 amino acids from the N-terminal region of human PAK2.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

PAK2, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. PAK2 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Expression is ubiquitous, with higher levels seen in skeletal muscle, ovary, thymus and spleen. PAK2 is autophosphorylated when activated by CDC42/p21. The protein structure contains 1 CRIB domain.

Specificity

Other Names

PAK2; Serine/threonine-protein kinase PAK 2; S6/H4 kinase; Gamma-PAK; PAK65; p21-activated kinase 2; p58; PAK-2p27; PAK-2p34; C-t-PAK2

NCBI Accession #

NP_002568.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

58043

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	The anti-PAK2 Pab (Cat# 102-17702) is used in Western blot to detect PAK2 in ovary cell lysate. Data is kindly provided by Elena Black from Boston University (Boston, MA).
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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