Anti-PC (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rabbit
Accession Number	P11498
Gene Id	5091
Gene Symbols	PC
Protein Name / Synonyms	PC (N-term)
Clonality	Polyclonal
Preparation	This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human PC.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq].

Specificity

Predicted Reactivity

Rat, Bovine

Other Names

PC; Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase

NCBI Accession #

NP_000911.2;NP_001035806.1;NP_071504.2

Other Accession #

P52873; Q05920; Q29RK2; NP_001035806.1; NP_000911.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

129634

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	PC Antibody (N-term) (Cat# 102-11597) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PC antibody detected the PC protein (arrow).
	PC Antibody (N-term) (Cat# 102-11597)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PC Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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