Anti-PDP1 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9P0J1
Gene Id	54704
Gene Symbols	PDP1
Protein Name / Synonyms	PDP1 (Center)
Clonality	Polyclonal
Preparation	This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.
Concentration (lot specific)	0.330 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Specificity

Other Names

PDP1; PDP; PPM2C; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1

NCBI Accession #

NP_001155251.1;NP_001155252.1;NP_001155253.1;NP_060914.2

Other Accession #

NP_001155253.1; NP_001155252.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

61054

Recommended Dilutions

IHC: 1:10-50; WB: 1:1000

	PDP1 Antibody (Center) (Cat# 102-11573)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDP1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
	PDP1 Antibody (Center) (Cat# 102-11573) western blot analysis in Jurkat,HepG2,293 cell line lysates (35ug/lane).This demonstrates the PDP1 antibody detected the PDP1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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