Anti-PDZK1 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q5T2W1
Gene Id	5174
Gene Symbols	PDZK1
Protein Name / Synonyms	PDZK1 (Center)
Clonality	Polyclonal
Preparation	This PDZK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human PDZK1.
Concentration (lot specific)	0.350 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).

Specificity

Other Names

PDZK1; CAP70; NHERF3; PDZD1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; CFTR-associated protein of 70 kDa; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3

NCBI Accession #

NP_001188254.1;NP_001188255.1;NP_002605.2

Other Accession #

A8MUH7; NP_002605.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

57129

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	PDZK1 Antibody (Center) (Cat# 102-12687) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PDZK1 antibody detected the PDZK1 protein (arrow).
	PDZK1 Antibody (Center) (102-12687)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDZK1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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