Anti-PGR/PR (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P06401
Gene Id	5241
Gene Symbols	PGR
Protein Name / Synonyms	PGR/PR (C-term)
Clonality	Polyclonal
Preparation	This PGR/PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human PGR/PR.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	IF, Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.

Specificity

Other Names

PGR; NR3C3; Progesterone receptor; Nuclear receptor subfamily 3 group C member 3

NCBI Accession #

NP_000917.3;NP_001189403.1;NP_001258091.1

Other Accession #

NP_000917.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

98981

Recommended Dilutions

IF: 1:10-50; WB: 1:1000

Fluorescent image of U251 cell stained with PGR/PR Antibody (C-term)(Cat# 102-14207).U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with PGR/PR primary antibody (1:25, 1 h at 37^°). For secondary antibody, Alexa Fluor^® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37^°).Cytoplasmic actin was counterstained with Alexa Fluor^® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37^°).PGR/PR immunoreactivity is localized to Nucleus significantly and Vesicles weakly.

PGR/PR Antibody (C-term) (Cat# 102-14207) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PGR/PR antibody detected the PGR/PR protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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