Anti-Phospho-ANTXR1 (Y425) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9H6X2
Gene Id	84168
Gene Symbols	ANTXR1
Protein Name / Synonyms	Phospho-ANTXR1(Y425)
Clonality	Polyclonal
Preparation	This ANTXR1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y425 of human ANTXR1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Dot Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

ANTXR1; ATR; TEM8; Anthrax toxin receptor 1; Tumor endothelial marker 8

NCBI Accession #

NP_060623.2;NP_115584.1;NP_444262.1

Other Accession #

Q0PMD2; Q9CZ52

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

62789

Recommended Dilutions

DB: 1:500

Dot blot analysis of anti-Phospho-ANTXR1-pY425 Antibody (Cat# 102-15491) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products