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Anti-Phospho-BCL2L1-S62 Antibody
Catalog #: 144-50680
Phospho-BCL2L1-S62 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | Q07817 |
| Gene Id | 598 |
| Gene Symbols | BCL2L1 |
| Protein Name / Synonyms | BCL2L1, BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52, BCL2 like 1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IHC, IF |
| Research Area | Apoptosis, Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Dilutions
WB 1:500 - 1:2000; IHC 1:50 - 1:100; IF 1:50 - 1:100
Format
Calculated MW
18kDa/25-26kDa
Observed MW
30kDa
Immunogen
A phospho specific peptide corresponding to residues surrounding S62 of human BCL2L1
Modification
Phospho S62
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.